A Genome-Wide Approach to Discovery of Small RNAs Involved in Regulation of Virulence in Vibrio cholerae
Identifieur interne : 000496 ( Main/Exploration ); précédent : 000495; suivant : 000497A Genome-Wide Approach to Discovery of Small RNAs Involved in Regulation of Virulence in Vibrio cholerae
Auteurs : Evan S. Bradley ; Kip Bodi ; Ayman M. Ismail ; Andrew CamilliSource :
- PLoS Pathogens [ 1553-7366 ] ; 2011.
Abstract
Small RNAs (sRNAs) are becoming increasingly recognized as important regulators in bacteria. To investigate the contribution of sRNA mediated regulation to virulence in
Url:
DOI: 10.1371/journal.ppat.1002126
PubMed: 21779167
PubMed Central: 3136459
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Genome-Wide Approach to Discovery of Small RNAs Involved in Regulation of Virulence in <italic>Vibrio cholerae</italic></title><author><name sortKey="Bradley, Evan S" sort="Bradley, Evan S" uniqKey="Bradley E" first="Evan S." last="Bradley">Evan S. Bradley</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bodi, Kip" sort="Bodi, Kip" uniqKey="Bodi K" first="Kip" last="Bodi">Kip Bodi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ismail, Ayman M" sort="Ismail, Ayman M" uniqKey="Ismail A" first="Ayman M." last="Ismail">Ayman M. Ismail</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Camilli, Andrew" sort="Camilli, Andrew" uniqKey="Camilli A" first="Andrew" last="Camilli">Andrew Camilli</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21779167</idno><idno type="pmc">3136459</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136459</idno><idno type="RBID">PMC:3136459</idno><idno type="doi">10.1371/journal.ppat.1002126</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000466</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000466</idno><idno type="wicri:Area/Pmc/Curation">000465</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000465</idno><idno type="wicri:Area/Pmc/Checkpoint">000297</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000297</idno><idno type="wicri:Area/Ncbi/Merge">000178</idno><idno type="wicri:Area/Ncbi/Curation">000178</idno><idno type="wicri:Area/Ncbi/Checkpoint">000178</idno><idno type="wicri:doubleKey">1553-7366:2011:Bradley E:a:genome:wide</idno><idno type="wicri:Area/Main/Merge">000498</idno><idno type="wicri:Area/Main/Curation">000496</idno><idno type="wicri:Area/Main/Exploration">000496</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Genome-Wide Approach to Discovery of Small RNAs Involved in Regulation of Virulence in <italic>Vibrio cholerae</italic></title><author><name sortKey="Bradley, Evan S" sort="Bradley, Evan S" uniqKey="Bradley E" first="Evan S." last="Bradley">Evan S. Bradley</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bodi, Kip" sort="Bodi, Kip" uniqKey="Bodi K" first="Kip" last="Bodi">Kip Bodi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ismail, Ayman M" sort="Ismail, Ayman M" uniqKey="Ismail A" first="Ayman M." last="Ismail">Ayman M. Ismail</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Camilli, Andrew" sort="Camilli, Andrew" uniqKey="Camilli A" first="Andrew" last="Camilli">Andrew Camilli</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS Pathogens</title><idno type="ISSN">1553-7366</idno><idno type="eISSN">1553-7374</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Small RNAs (sRNAs) are becoming increasingly recognized as important regulators in bacteria. To investigate the contribution of sRNA mediated regulation to virulence in <italic>Vibrio cholerae</italic>, we performed high throughput sequencing of cDNA generated from sRNA transcripts isolated from a strain ectopically expressing ToxT, the major transcriptional regulator within the virulence gene regulon. We compared this data set with ToxT binding sites determined by pulldown and deep sequencing to identify sRNA promoters directly controlled by ToxT. Analysis of the resulting transcripts with ToxT binding sites <italic>in cis</italic> revealed two sRNAs within the <italic>Vibrio</italic> Pathogenicity Island. When deletions of these sRNAs were made and the resulting strains were competed against the parental strain in the infant mouse model of <italic>V. cholerae</italic> colonization, one, TarB, displayed a variable colonization phenotype dependent on its physiological state at the time of inoculation. We identified a target of TarB as the mRNA for the secreted colonization factor, TcpF. We verified negative regulation of TcpF expression by TarB and, using point mutations that disrupted interaction between TarB and <italic>tpcF</italic> mRNA, showed that loss of this negative regulation was primarily responsible for the colonization phenotype observed in the TarB deletion mutant.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Koch, R" uniqKey="Koch R">R Koch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaper, Jb" uniqKey="Kaper J">JB Kaper</name></author><author><name sortKey="Morris, Jg" uniqKey="Morris J">JG Morris</name></author><author><name sortKey="Levine, Mm" uniqKey="Levine M">MM Levine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Childers, Bm" uniqKey="Childers B">BM Childers</name></author><author><name sortKey="Klose, Ke" uniqKey="Klose K">KE Klose</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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uniqKey="Terpe K">K Terpe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Vl" uniqKey="Miller V">VL Miller</name></author><author><name sortKey="Mekalanos, Jj" uniqKey="Mekalanos J">JJ Mekalanos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pepke, S" uniqKey="Pepke S">S Pepke</name></author><author><name sortKey="Wold, B" uniqKey="Wold B">B Wold</name></author><author><name sortKey="Mortazavi, A" uniqKey="Mortazavi A">A Mortazavi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Camilli, A" uniqKey="Camilli A">A Camilli</name></author><author><name sortKey="Mekalanos, Jj" uniqKey="Mekalanos J">JJ Mekalanos</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bodi, Kip" sort="Bodi, Kip" uniqKey="Bodi K" first="Kip" last="Bodi">Kip Bodi</name><name sortKey="Bradley, Evan S" sort="Bradley, Evan S" uniqKey="Bradley E" first="Evan S." last="Bradley">Evan S. Bradley</name><name sortKey="Camilli, Andrew" sort="Camilli, Andrew" uniqKey="Camilli A" first="Andrew" last="Camilli">Andrew Camilli</name><name sortKey="Ismail, Ayman M" sort="Ismail, Ayman M" uniqKey="Ismail A" first="Ayman M." last="Ismail">Ayman M. Ismail</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= A Genome-Wide Approach to Discovery of Small RNAs Involved in Regulation of Virulence in Vibrio cholerae
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